Surapunnaga (Ochrocarpus longifolius)

Recent Research on Punnaga (Ochrocarpus longifolius)

• Laloo, Dr. Damiki. (2010). Quality Control Studies of Ochrocarpus longifolius Flower Buds. Pharmacognosy Journal. 2. 118- 123. The flower buds of Ochrocarpus longifolius Benth. & Hook f. is the crude drug which has been used for the pharmacognostical standardization as per WHO guidelines- 1998 and IHP- 2002. The plant is a tree. Authentication and identification have been done taxonomically. The dried flower buds are light brown and round in shape. Oblate to suboblate pollen grains, lignified, spiral, and elongated xylem vessels have been found. Stone cells, thick-bordered tracheids, and anther fractions have been observed in powder drug microscopy. Foreign matter (0.29 %), loss on drying (13.16 %), total ash (6.30 %), acid insoluble ash (0.43 %), water soluble ash (1.97 %), alcohol soluble extractive (16.03 %), water soluble extractive (12.57 %), volatile oil (0.10 %), foaming index 200 and swelling index 0.36 ml of the crude drug have been obtained. A fingerprint of fluorescence has been observed in fluorescence analysis. Preliminary phytochemical screening of the methanolic extract of the crude drug has revealed the presence of glycosides, reducing sugars, phenolics, tannins, coumarins, sterols, flavanoids, saponins, and volatile oil. Total phenolics (138.30 ± 4.58), total tannins (133.0 ± 1.52), total flavonoids (41 ± 1.28), and total flavonol (0.56 ± 0.04) content in mg/gm of plant extract have been estimated. Different amounts of chlorinated and phosphated pesticides were obtained in the crude drug. By establishing the quality parameters for Ochrocarpus longifolius, it can be a better-used plant for further research and for trade and commerce.
• Laloo, Dr. Damiki & Sahu, Alakh. (2011). Antioxidant activities of three Indian commercially available Nagakesar: An in vitro study. J Chem Pharm Res. 3. 277- 283. The objective of the present study was to evaluate the in vitro antioxidant activity of the methanolic extract of various commercial Nagakesar available in the Indian market. The three commercially available Nagakesar used in the present study are Mesua ferrea Linn., Ochrocarpus longifolius Benth & Hook.f, and Cinnamomum wightii Meissn. The in vitro antioxidant models studied are the total antioxidant capacity by phosphor-molybdenum method, 2, 2- diphenyl- 1-picrylhydrazyl (DPPH) free radical scavenging, superoxide anion radical scavenging, and hydrogen peroxide scavenging activity. The radical scavenging activities of the three Nagakesar extracts were compared to the standard ascorbic acid and rutin, incorporating the statistical linear regression equation. Among the three Nagakesar flowers, Cinnamomum wightii was found to exhibit the highest antioxidant and potent radical scavenging activity as compared to Mesua ferrea and Ochrocarpus longifolius. A positive, significant linear relationship between antioxidant activity and total phenolic content (R 2 = 0.652) showed that phenolic compounds were the dominant antioxidant components in the tested flower extract. In addition to the antioxidant activity, the thin-layer chromatography (TLC) fingerprinting and the quantitative estimation of the total phenolic (Folin-Ciocalteau method), flavonoid, and flavonol content were also performed.
• Liu, Shulan & Huang, Xueling & Zhong, Shunhua & Ma, Yonghui & Wei, Feng & Zhang, Yuye & Li, Jin & Pang, Kejian & Zhao, Ping & Yang, Xinzhou. (2024). Seven New Compounds from Dried Flower Buds of Ochrocarpus Longifolius. 10. 2139/ ssrn. 4826893.
• Yatish, K.V. & Lalithamba, H.S. & Suresh, Dr. R., & Latha, H. (2019). Ochrocarpus longifolius assisted in the green synthesis of CaTiO3 nanoparticles for biodiesel production and their kinetic study. Renewable Energy. 147. 10. 1016/ j. renene. 2019. 08. 139. In this study, calcium titanoparticles (CaTiO3 NPs) were synthesized through solution combustion synthesis (SCS) by using Ochrocarpus longifolius leaves extract as a novel fuel. The CaTiO3 NPs were successfully utilized in the biodiesel synthesis from dairy waste scum oil (DWSO) as a heterogeneous base catalyst. The synthesized CaTiO3 NPs were characterized by SEM, XRD, TEM, BET, FT-IR, and CO2- TPD. Response surface methodology (RSM) in conjunction with central composite design (CCD) was utilized to determine the optimum conditions for biodiesel production by varying catalyst loading, molar ratio, and reaction time. The maximum 97.7 % yield of dairy waste scum oil methyl ester (DWSOME/biodiesel) was obtained for a molar ratio (methanol to DWSO) of 9:1, 1.80 wt% % catalyst loading, and 45 min reaction time with constant temperature (65 °C) and stirring speed (650 rpm). The CaTiO3 NPs show a good catalytic stability up to five cycles with a low loss of yield. The kinetic study of biodiesel production fits well with a pseudo-first-order reaction. For the transesterification reaction, 35.56 kJ/ mol of activation energy (Ea) was found. Finally, the DWSOME was characterized by HNMR, and the fuel properties were also determined and were in the range of ASTM standards.
• Poojary, Mahesha & Murthy K A, Dr. Vishnu & Adhikari, Airody. (2015). Extraction, characterization, and biological studies of phytochemicals from Mammea suriga. Journal of Pharmaceutical Analysis. 70. 10. 1016/ j. jpha. 2015. 01. 002. The present work involves the extraction of phytochemicals from the root bark of a well-known Indian traditional medicinal plant, viz. Mammea suriga, with various solvents and evaluation of their in vitro antimicrobial and antioxidant activities using standard methods. The phytochemical analysis indicates the presence of some interesting secondary metabolites like flavonoids, cardiac glycosides, alkaloids, saponins, and tannins in the extracts. Also, the solvent extracts displayed promising antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, and Cryptococcus neoformans with a zone of inhibition ranging from 20 to 33 mm. Further, results of their antioxidant screening revealed that aqueous extract (with IC50 values of 111.51± 1.03 and 31.05±  0.92 μg/ mL in total reducing power assay and DPHH radical scavenging assay, respectively) and ethanolic extract (with IC50 values of 128.00±  1.01 and 33.25± 0.89 μg/ mL in total reducing power assay and DPHH radical scavenging assay, respectively) were better antioxidants than standard ascorbic acid. Interestingly, FT-IR analysis of each extract established the presence of various biologically active functional groups in it.
• Pattanayak, Shibabrata. (2023). Anti-cancer plants and their therapeutic use as succulent biomedicine capsules. 13. 01- 50. 10. 52635/ eamr/ 13 (S) 01- 50. Cancer is a slow-developing non-communicable disease that causes a high rate of morbidity and mortality among sufferers. Apart from genetic predisposition, the main reasons for cancers are following the wrong lifestyle and food habits. The contemporary treatments of cancer aim to increase the life span of the sufferers and to reduce the severity of the disease, but such efforts have many serious side effects. Along with the correction of lifestyle, regular intake of selected succulent fruits, vegetables, and parts of anti-cancer plants, as well as some medicines, can combat almost all cancers. The succulent parts of every medicinal plant contain an enormous number of metabolites that act cumulatively together following various pathways inside the body. The nature-gifted succulent biomedicines that are considered edible in traditional uses have a far lesser chance of showing toxic effects than synthetic chemicals; isolated phytochemicals or their structural analogs obtained from any plant have actual characteristics like synthetic chemicals. There is possibly in-home neutralization of side effects and potentiation of the activities of each other by the metabolites present in the succulent plant parts. Anticancer medicinal plants can be used therapeutically for the prevention and cure of cancers at their early stages after some adaptive research on dose and toxicity. To avoid the problems of regional and seasonal availability of medicinal plants and other problems in their direct use as medicines, bio-preservatives added, and bioencapsulated succulent biomedicines can be produced, either singly or as some mixtures of the selected biomedicines. An outline of the production, storage, and global transportation of such anti-cancer biomedicines is displayed, and a list of 934 anticancer plants (including 124 edible fruits, 124 edible vegetables, and 114 other possibly non-toxic plant parts) with various details regarding their nature and efficacies is described in this article.
• Li, Chunmei & Jeong, Yoonhwa & Kim, Misook. (2017). Mammea longifolia Planch. And Triana Fruit Extract Induces Cell Death in the Human Colon Cancer Cell Line, SW480, via Mitochondria-Related Apoptosis and Activation of p53. Journal of Medicinal Food. 20. 485- 490. 10. 1089/ jmf. 2016. 3865. The methanol extract of Mammea longifolia Planch. The fruit of Triana (M. longifolia) was studied for anticancer and apoptotic effects in the SW480 colon cancer cell line. The apoptotic and necrotic effects of M. longifolia were detected by 3- (4, 5- dimethyl- 2-thiazolyl)- 2, 5- diphenyl- 2H tetrazolium bromide (MTT) and lactate dehydrogenase assays, respectively. One hundred μg/ mL of the extract killed ∼ 82.4 % of the cells; however, 2% of the deaths were related to necrosis. The morphological changes in M. longifolia- stimulated SW-480 cells were observed directly by light microscopy. A DNA fragmentation assay was employed to analyze the apoptosis induction. M. longifolia-treated SW-480 cells promoted the expression of Bax, Bad, cleaved-poly-ADP-ribose polymerase (PARP), and p53 proteins and decreased the protein expression of pro-caspases Bcl-2 and Bcl-XL. The ratios of Bax/Bcl-2 and cleaved-PARP/ PARP, predictive markers of apoptotic stimuli in cancer, increased and may play an important role in regulating the progression of apoptosis. The results suggested that M. longifolia induces cell death via mitochondrial-related apoptosis in SW-480 cells.
• Win, Nwet & Awale, Suresh & Esumi, Hiroyasu & Tezuka, Yasuhiro & Kadota, Shigetoshi. (2008). Novel anticancer agents, kayeassamins C−I from the flower of Kayea assamica of Myanmar. Bioorganic & medicinal chemistry. 16. 8653- 60. 10. 1016/ j. bmc. 2008. 07. 091. A CHCl3-soluble fraction of 70 % EtOH extract of the flower of Kayea assamica from Myanmar exhibited 100 % preferential cytotoxicity (PC (100)) against human pancreatic cancer PANC-1 cells under nutrient-deprived conditions at 1 microg/mL. Bioassay-guided fractionation and isolation afforded nine new coumarins, kayeassamins A (8), B (9), and C-I (1-7), together with nine known coumarins (10-18). The structures of these compounds were identified by extensive spectroscopic techniques as well as by comparison with published data. The absolute configuration at C-1′ of 1 was established as S-configuration by the modified Mosher method. All the isolates were evaluated for their in vitro preferential cytotoxicity using a novel anti-austerity strategy. Among them, the novel coumarins, kayeassamins A (8), B (9), D (2), E (3), and G (5) exhibited the most potent preferential cytotoxicity (PC (100) 1 microM) in a concentration- and time-dependent manner and induced apoptosis-like morphological changes of PANC- 1 cells within 24 h of treatment. Based on the observed cytotoxicity, structure-activity relationships have been established.
• Rathee, Jitesh & Hassarajani, Shyam & Chattopadhyay, Subrata. (2006). Antioxidant activity of Mammea longifolia bud extracts. Food Chemistry – FOOD CHEM. 99. 436- 443. 10. 1016/ j. foodchem. 2005. 08. 020. Mammea longifolia buds (nagkesar) are extensively used in India as a minor spice. The antioxidant activity of its methanol (NM) and aqueous-ethanol (NW) extracts was evaluated by several in vitro experiments, e.g., DPPH, hydroxyl, superoxide radicals, and H2O2- scavenging assays, as well as inhibition of Fe (II)-induced lipid peroxidation of rat liver mitochondria. The extracts were found to possess impressive antioxidant activity in all the tests, the activity of NW being higher than that of NM in most of the assays. The differential activities of NW and NM could be correlated with their respective total phenolic, flavonoid, and proanthocyanidin contents.
• Pandya, Shachi & Dhiman, Kamini & Dei, Laxmipriya & Thakar, A. (2014). PHARMACOGNOSTICAL AND PHYTO-CHEMICAL EVALUATION OF PIPPALYADI YOGA: A POLYHERBAL FORMULATION. International journal of Ayurveda and Pharma research. 2. 116- 123. Pippalyadi Yoga is Churna Kalpana, described by Acharya Chakrapani in Vandhyatva (infertility). Ovulatory dysfunction is the prime cause of Infertility in the world. Pippalyadi Yoga is useful for patients, especially those having Anovulation, which is known as Abeejatva in Ayurveda. So a new pharmaceutical preparation, Pippalyadi Yoga in the form of Churna (powder), was tried to standardize, which is economical in terms of time and machinery usage. Pharmacognostical and phytochemical observations revealed the specific characters of all active constituents used in the preparation. The present work was carried out to standardize the finished product of Pippalyadi Yoga to confirm its identity, quality, and purity. The presence of stone cells, oil globules, olio resin cells, parenchymatous cells, oval & beaker-shaped starch grains, and pollen grains were the characteristic features observed in the microscopy of the prepared drug. Phyto-chemical analysis showed Loss on drying 10.07 % w/ w, ash value 6.55 % w/ w, water soluble extract 14 % w/ w, methanol soluble 13.40 % w/w, particle consistency above 60 mesh 4.10 % w/ w, between 60-85 mesh 9.20 % w/w, between 85-120 mesh 13.30 % w/w & below 120 mesh 73.37 % w/w & pH 5.0. HPTLC of Pippalyadi Yoga is the preliminary quantitative analysis, which shows 8 prominent spots at Rf. 0.09, 0.61, 0.67, 0.74, 0.80, 0.86, 0.91, 1.00 in UV 254 nm and 7 prominent spots at Rf. 0.06, 0.17, 0.63, 0.67, 0.75, 0.82, 0.88 in UV 366 nm. Pippalyadi Yoga, a polyherbal formulation of 4 ingredients, was prepared, and an HPTLC fingerprint profile was developed. It can be considered the pharmacopeial standard of Pippalyadi Yoga.
• Péroumal, Armelle & Adenet, Sandra & Rochefort, Katia & Fahrasmane, Louis & Aurore, Guylene. (2017). Variability of traits and bioactive compounds in the fruit and pulp of six mamey apple ( Mammea americana L.) accessions. Food Chemistry. 234. 10. 1016/ j. food chem. 2017. 04. 145. Our objective was to compare fruit morphology, physical chemistry, and bioactive compounds content of the edible pulp of six Mammea americana accessions. The results showed that this fruit was rather big, weighing on average 600 to 1100 g depending on the accession, and spherical to oblate-shaped. The pulp represented between 50 and 70 % of the weight of the whole fruit. The pulp adhered only partially to the seeds in 5 of the 6 accessions studied, while the last one exhibited full adherence. The fresh pulp was acidic, sweet, succulent, and crunchy. The fruits studied had a variety of qualities, providing various opportunities for post-harvest uses, such as fruit salads, nectar preparation, jams and jellies, or export. We have established for the first time the total phenolic compounds and total flavonoid contents in the pulp of mamey apple fruits. The pulp color was highly correlated with total phenolic compounds and total carotenoid contents.
• Lu, Ping & Li, Miao & Lou, Yiceng & Su, Fengping & Li, Hongling & Zhao, Xiang & Cheng, Yali. (2014). Antiproliferative effects of n-butyl-β-D-fructofuranoside from Kangaisan on Bel-7402 cells. Indian journal of pharmacology. 46. 69- 75. 10. 4103/ 0253- 7613. 125175. Kangaisan is a powdered compound prescription of Traditional Chinese Medicine that has been used in cancers for many years in Hubei province, China. The purpose of this study was to investigate the antitumor effects of Kangaisan and screen bioactive components. 3- (4, 5- Dimethythiazol-2-yl-2-yl- 2- yl)- 2, 5 diphenyl-tetrazolium bromide (MTT) assay, flow cytometry, DNA (Deoxyribonucleic acid) fragmentation assay, Western blot, and real-time polymerase chain reaction were used to investigate the antiproliferation effect of n-butyl-β-D-fructofuranoside on Bel-7402 cells. All experiments were performed in triplicate, and the results were expressed as mean ± standard deviation. Statistical analysis was performed with analysis of variance using Origin 8.0 software. It was illustrated that treatment of Bel- 7402 cells with various concentrations of n- butyl- β- D-fructo- furanoside resulted in growth inhibition in both a dose-dependent and time-dependent manner. The arrest of the G0/ G1 phase was also induced (P<  0.05). The increase in sub-G1 cell population indicated the apoptotic characteristic (P < 0.05). Furthermore, the emergence of DNA fragmentation and the increase of the Bax/ Bcl-2 ratio and p53 expression suggested the possible mitochondrial apoptotic pathway (P < 0.05). The results illustrate that Kangaisan showed anticancer effects, and n-butyl-β-D-fructofuranoside extracted from Kangaisan can suppress Bel-7402 cells via interfering with the cell cycle and by inducing apoptosis.
• Poojary, Mahesha & Passamonti, Paolo & Adhikari, Airody. (2016). Green Synthesis of Silver and Gold Nanoparticles Using Root Bark Extract of Mammea suriga: Characterization, Process Optimization, and Their Antibacterial Activity. BioNanoScience. 6. 10. 1007/ s12668- 016- 0199-8. The present study reports the green synthesis of silver and gold nanoparticles (NPs) from their respective precursors AgNO3 and HAuCl4, using the root bark extract of Mammea suriga. Further, it describes the influence of various reaction parameters, such as pH, temperature, precursor concentration, and volume of the extract, on the morphology and size of the newly synthesized NPs. The biosynthesized NPs were characterized using UV–Vis spectroscopy, SEM, EDX, XRD, and FTIR. The formation of Ag and Au NPs was confirmed by their UV–Vis spectra. Ag NPs were efficiently synthesized at pH 10, with a precursor concentration of 1 mM of AgNO3 and a reaction temperature of 80 °C, while Au NPs were successfully obtained at pH 8, with precursor concentrations of either 1 or 3 mM HAuCl4, and the reaction was maintained at room temperature. The SEM study revealed that the particle size decreases with an increase in the extract volume used in the reaction. The XRD analysis confirmed the formation of metallic Ag and Au NPs having an average size of 50 and 22 nm, respectively. Further, the FTIR spectral data established the role of various functional groups of biomolecules involved in bio-reduction as well as the capping of NPs. The in vitro antibacterial screening results indicated that the NPs are potential antibacterial agents. Conclusively, the overall study showed that the root bark extract of M. suriga is an excellent, eco-friendly, and non-toxic source for the synthesis of biologically active Ag and Au NPs at optimal conditions.
• Shastri, Sudhesh & V, Krishna & B, Ravishankar & Kumar N M, Vinay & G P, Chethan Kumara. (2017). ANTIOXIDANT AND HEPATOPROTECTIVE POTENTIAL OF MAMMEA SURIGA AQUEOUS EXTRACT AGAINST CCL4-INDUCED HEPATOTOXICITY IN RAT MODELS. World Journal of Pharmaceutical Research. 6. 1396- 1409. 10. 20959/ wjpr- 20176- 8696. Mammea suriga is an endemic tree of the family Calophyllaceae, which has important traditional usage as a medication. A detailed study was performed on the antioxidant activity of M. suriga flower bud aqueous extract by in vitro chemical analyses and carbon tetrachloride (CCl₄) induced hepatotoxicity in Albino rats. The extract was subjected to preliminary phytochemical screening for various constituents, which revealed the presence of flavonoids, phenols, and terpenoids. The total phenolic contents (79.97 µg/ mg) and total flavonoid contents (113 µg/ mg) of the extract were found to be higher. 200 and 400 mg/ kg doses of aqueous extract, CCl4, water, and ascorbic acid (100 mg/ kg) were used as treatment groups. The blood samples were analyzed for levels of biochemical markers, and tissue samples were subjected to estimation of liver antioxidant and histopathological studies. Analysis of the extract-treated rats (400 mg/ kg) showed an elevation of lipid peroxidation (0.68± 0.01 nmol mg 4 -1 of protein). Moreover, the biochemical parameters in serum, like SGOT, SGPT, total cholesterol, total creatinine, total protein (TP), and urea, were also improved in the treated groups compared to the control. The oral administration of doses of M. suriga extracts significantly protected the hepatic cells from damage. This study proved that M. suriga could be taken as a good natural source of the antioxidant agent.
• Laphookhieo, Surat & Promnart, Phunrawie & Syers, John & Ponglimanont, Chanita & Karalai, Chatchanok. (2007). Coumarins and xanthones from the seeds of Mammea siamensis. J. Braz. Chem. Soc. 18. 1077- 1080. 10. 1590/ S0103- 50532007000500031. Uma cumarina inédita, mammea E/ BB ciclo D (1), juntamente com cinco compostos conhecidos, mammea E/ BA ciclo D (2), suragina C (3), terapina B (4), 1, 7- dihidroxixantona (5) e 1- hidroxi- 5- metoxyxantona (6), foram isolados de sementes de Mammea siamensis. Suas estruturas foram caracterizadas usando dados de RMN 1D e 2D. Suragina C e terapina B mostraram atividade citotóxica contra adenocarcinoma de mama (MCF- 7), cancer cervical humano (HeLa), câncer de colon (HT-29) e cancer oral humano (KB). A new coumarin, mammea E/ BB cyclo D (1), together with five known compounds, mammea E/ BA cyclo D (2), suragin C (3), therapin B (4), 1, 7- dihydroxyxanthone (5) and 1- hydroxy- 5- methoxyxanthone (6), were isolated from the seeds of Mammea siamensis. Their structures were characterized using 1D and 2D NMR spectral data. Suragin C and therapin B showed cytotoxic activity against breast adenocarcinoma (MCF- 7), human cervical cancer (HeLa), colon cancer (HT- 29) and human oral cancer (KB).
• Poojary, Mahesha & Murthy K A, Dr. Vishnu & Adhikari, Airody. (2015). Extraction, characterization, and biological studies of phytochemicals from Mammea suriga. Journal of Pharmaceutical Analysis. 70. 10. 1016/ j. jpha. 2015. 01. 002. The present work involves the extraction of phytochemicals from the root bark of a well-known Indian traditional medicinal plant, viz. Mammea suriga, with various solvents and evaluation of their in vitro antimicrobial and antioxidant activities using standard methods. The phytochemical analysis indicates the presence of some interesting secondary metabolites like flavonoids, cardiac glycosides, alkaloids, saponins, and tannins in the extracts. Also, the solvent extracts displayed promising antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, and Cryptococcus neoformans with a zone of inhibition ranging from 20 to 33 mm. Further, results of their antioxidant screening revealed that aqueous extract (with IC50 values of 111.51± 1.03 and 31.05± 0.92 μg/ mL in total reducing power assay and DPHH radical scavenging assay, respectively) and ethanolic extract (with IC50 values of 128.00± 1.01 and 33.25± 0.89 μg/ mL in total reducing power assay and DPHH radical scavenging assay, respectively) were better antioxidants than standard ascorbic acid. Interestingly, FT-IR analysis of each extract established the presence of various biologically active functional groups in it.
• Shastri, Sudhesh & V, Krishna & Kumar S, Ravi & R, Santosh & R, Venkatesh & K., Pradeepa. (2016). Phytochemical analysis, antibacterial property, and molecular docking studies of Mammea suriga Kosterm.. World Journal of Pharmaceutical Sciences. 4. 331-340. Mammea suriga is an endemic, medicinal, and economically important tree belonging to the family Callophyllaceae, distributed along the Western Ghats of India. The present study focuses on phytochemical aspects, antibacterial activity against clinical pathogenic bacterial strains, and docking studies of extracts of M. suriga. The GC- MS analysis of flower bud oil showed 69 phyto- compounds among them Benzene, 1, 1′- (1- methyl- ethylidene) bis [4- (2-propenyloxy)- and Cholestan- 19- ol, 5, 6- epoxy- 3- fluoro-, (3. beta.,   alpha, 6. alpha.) are the major components. Stem bark extract showed 48 phyto- compounds among them 17- Oxo- 6. alpha. -pentyl- 4- nor- 3, 5-secoandrostan- 3- oic acid methyl ester is the major component. The stem bark and flower bud extract exhibited significant antibacterial activity against S. Typhi (7.00± 0.33) when compared to the standard drug (7.00± 0.00). In silico, molecular docking studies revealed that Cholestan-19-ol, 5, 6-epoxy-3-fluoro-, (3. beta., 5. alpha., 6. alpha.), a second major component of flower bud oil, exhibited more efficiency against the key enzyme of bacterial G6PS. This investigation supports the medicinal claim of suragi oil as an effective antibacterial agent.
• Laphookhieo, Surat & Promnart, Phunrawie & Syers, John & Ponglimanont, Chanita & Karalai, Chatchanok. (2007). Coumarins and xanthones from the seeds of Mammea siamensis. J. Braz. Chem. Soc. 18. 1077- 1080. 10. 1590/ S0103- 50532- 007000- 500031. Uma cumarina inedita, mammea E/ BB ciclo D (1), juntamente com cinco compostos conhecidos, mammea E/ BA ciclo D (2), suragina C (3), terapina B (4), 1, 7- dihidroxixantona (5) e 1- hidroxi- 5- metoxyxantona (6), foram isolados de sementes de Mammea siamensis. Suas estruturas foram caracterizadas usando dados de RMN 1D e 2D. Suragina C e terapina B mostraram atividade citotoxica contra adenocarcinoma de mama (MCF- 7), cancer cervical humano (HeLa), cancer de colon (HT-29) e cancer oral humano (KB). A new coumarin, mammea E/ BB cyclo D (1), together with five known compounds, mammea E/BA cyclo D (2), suragin C (3), therapin B (4), 1, 7- dihydroxy- xanthone (5) and 1- hydroxy- 5- methoxyxanthone (6), were isolated from the seeds of Mammea siamensis. Their structures were characterized using 1D and 2D NMR spectral data. Suragin C and therapin B showed cytotoxic activity against breast adenocarcinoma (MCF- 7), human cervical cancer (HeLa), colon cancer (HT- 29) and human oral cancer (KB).
• Liu, Shu-Lan & Huang, Xue-Ling & Zhong, Shun-Hua & Ma, Yong-Hui & Feng, Wei & Zhang, Yu-Ye & Li, Jin & Pang, Ke-Jian & Zhao, Ping & Yang, Xin-Zhou. (2024). Seven undescribed compounds from dried flower buds of Ochrocarpus longifolius. Phytochemistry. 229. 114307. 10. 1016/ j. phytochem. 2024. 114307.